Publications

PEER REVIEWED ORIGINAL RESEARCH PAPERS
(Total citations > 5000, H-index = 27)
Science China Life Sciences | 2024 July 9
Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit
Zhen Li, Xuefei Li, Jingxia Lin, Yangming Wang, *Huiqing Cao, *Jiajian Zhou
PubMed  PDF  doi: 10.1007/s11427-023-2594-3 
Nature Genetics | 2024 Jan 9; 56 (1)
Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human
#Wenze Huang, #Tuanlin Xiong, #Yu-Ting Zhao, Jian Heng, Ge Han, Pengfei Wang, Zhihua Zhao, Ming Shi, Juan Li, Jia-Zhen Wang, Yi-Xia Wu, Feng Liu, *Jianzhong Jeff Xi, *Yangming Wang, *Qiangfeng Cliff Zhang
PubMed  PDF  doi: 10.1038/s41588-023-01620-7 
Science Bulletin | 2023 Nov 21; 69 (1)
Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein
Fandi Shi, Kun Zhang, Qi-Xuan Cheng, Shiyou Che, Shuxin Zhi, Zhenyu Yu, Fei Liu, Fei-Fei Duan, *Yangming Wang, *Na Yang
PubMed  PDF  doi: 10.1016/j.scib.2023.11.041 
ACS Nano | 2023 Nov 08; 22 (17)
MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice
Xiyang Wei, Shicheng Yu, Tinghong Zhang, Liansheng Liu, Xu Wang, Xiaodan Wang, Yun-Shen Chan, Yangming Wang, Shu Meng, *Ye-Guang Chen
PubMed  PDF  doi: 10.1021/acsnano.3c08030 
Biofabrication | 2023 Aug 08; 15 (4)
Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly
Xiao-Shan Zhang, Gang Xie, Honghao Ma, Shuangjin Ding, Yi-Xia Wu, Yuan Fei, Qiang Cheng, Yanyi Huang, *Yangming Wang
PubMed  PDF  doi: 10.1088/1758-5090/acee21 
Trends in Cell Biology | 2023 Jul 05; 31 (1)
miRNA dosage control in development and human disease
#Yingzi Cui, #Ye Qi, #Li Ding, Shuangjin Ding, Zong-Lin Han, *Yangming Wang, #*Peng Du
PubMed  PDF  doi: 10.1016/j.tcb.2023.05.009 
Nature Communications | 2023 Feb 16; 14 (1)
DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing
#Li Mi, #Ming Shi, Yu-Xuan Li, Gang Xie, Xichen Rao, Damu Wu, Aimin Cheng, Mengxiao Niu, Fengli Xu, Ying Yu, Ning Gao, Wensheng Wei, Xianhua Wang, *Yangming Wang
PubMed  PDF  doi: 10.1038/s41467-023-36600-2 
Protein & Cell | 2022 Jul 15; 14 (2)
A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions
Rujin Huang, Jinyang Liu, Xi Chen, Ying Zhi, Shuangyuan Ding, Jia Ming, Yulin Li, Yangming Wang, *Jie Na
PubMed  PDF  doi: 10.1093/procel/pwac019 
WIREs RNA | 2022 Apr 08; 14 (1)
Controlling CRISPR-Cas9 by guide RNA engineering
Lu-Feng Hu, Yu-Xuan Li, Jia-Zhen Wang, Yu-Ting Zhao, *Yangming Wang
PubMed  PDF  doi: 10.1002/wrna.1731 
Science China Life Sciences | 2022 Apr 01; 65 (10)
KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2
Shao-Hua Wang, Jing Hao, Chao Zhang, Fei-Fei Duan, Ya-Tzu Chiu, Ming Shi, Xin Huang, Jihong Yang, *Huiqing Cao, *Yangming Wang
PubMed  PDF  doi: 10.1007/s11427-021-2076-x 
Science Bulletin | 2021 Jul 01; 66 (13)
Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells
*Wen-Ting Guo, Shao-Hua Wang, Xiao-Shan Zhang, Ming Shi, Fei-Fei Duan, Jing Hao, Kai-Li Gu, Li Quan, Yixia Wu, Zhiyong Liang, *Yangming Wang
PubMed  PDF  doi: 10.1016/j.scib.2021.03.005 
Cell Discovery | 2021 Jun 15; 7 (1)
Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron
Yu-Ting Zhao, *Yangming Wang
PubMed  PDF  doi: 10.1038/s41421-021-00272-3 
Essays in Biochemistry | 2020 Dec 7; 64 (6)
microRNA regulation of pluripotent state transition
Shao-Hua Wang, Chao Zhang, *Yangming Wang
PubMed  PDF  doi: 10.1042/ebc20200028 
Cell Proliferation | 2020 Sep 29; 53 (11)
KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells
#Jing Hao, #Xi Yang, Chao Zhang, Xue-Tao Zhang, Ming Shi, Shao-Hua Wang, Li Mi, Yu-Ting Zhao, Huiqing Cao, *Yangming Wang
PubMed  PDF  doi: 10.1111/cpr.12914 
Cell | 2020 Apr 01; 181 (3)
Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells
#Chun-Jie Guo, #Xu-Kai Ma, Yu-Hang Xing, Chuan-Chuan Zheng, Yi-Feng Xu, Lin Shan, Jun Zhang, Shao-Hua Wang, Yangming Wang, Gordon G. Carmichael, Li Yang, *Ling-Ling Chen
PubMed  PDF  doi: 10.1016/j.cell.2020.03.006 
Cell Reports | 2020 Jan 01; 30 (1)
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States
#Kaixin Wu, #He Liu, Yaofeng Wang, Jiangping He, Shuyang Xu, Yaping Chen, Junqi Kuang, Jiadong Liu, Lin Guo, Dongwei Li, Ruona Shi, Li Shen, Yangming Wang, Xiaofei Zhang, Jie Wang, Duanqing Pei, *Jiekai Chen
PubMed  PDF  doi: 10.1016/j.celrep.2019.12.010 
Cell Discovery | 2019 Dec 10; 5 (1)
Cellular redox state as a critical factor in initiating early embryonic-like program in embryonic stem cells
#Chao Zhang, #Yao-Long Yan, #Jing Hao, Yangming Wang
PubMed  PDF  doi: 10.1038/s41421-019-0127-5 
International Journal of Molecular Sciences | 2019 Sep 05; 20 (18)
Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells
Ming Shi, Jing Hao, Xi-Wen Wang, Le-Qi Liao, *Huiqing Cao, *Yangming Wang
PubMed  PDF  doi: 10.3390/ijms20184345 
Stem Cell Research | 2019 Jul 01; 38
Pathogenic mechanism and gene correction for LQTS-causing double mutations in KCNQ1 using a pluripotent stem cell model
Zhen Wang, Lipeng Wang, Wenling Liu, Dayi Hu, Yuanfeng Gao, Qing Ge, Xin Liu, Lei Li, *Yangming Wang, *Shiqiang Wang, *Cuilan Li
PubMed  PDF  doi: 10.1016/j.scr.2019.101483 
PLOS Biology | 2019 Jun 21; 17 (6)
DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program
#Yao-Long Yan, #Chao Zhang, Jing Hao, Xue-Lian Wang, Jia Ming, Li Mi, Jie Na, Xinli Hu, *Yangming Wang
PubMed  PDF  doi: 10.1371/journal.pbio.3000324 
Nature Communications | 2019 Mar 25; 10 (1)
A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells
#Ya-Pu Li, #Fei-Fei Duan, Yu-Ting Zhao, Kai-Li Gu, Le-Qi Liao, Huai-Bin Su, Jing Hao, Kun Zhang, Na Yang, *Yangming Wang
PubMed  PDF  doi: 10.1038/s41467-019-08911-w 
Protocol Exchange | 2019 Feb 25
A protocol to build microRNA-inducible CRISPR-Cas9 platform
#Xi-Wen Wang, #Lu-Feng Hu, Jing Hao, Le-Qi Liao, Ya-Tzu Chiu, Ming Shi, *Yangming Wang
PDF  doi: 10.1038/protex.2019.001 
Nature Cell Biology | 2019 Feb 25; 21 (4)
A microRNA-inducible CRISPR–Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool
#Xi-Wen Wang, #Lu-Feng Hu, Jing Hao, Le-Qi Liao, Ya-Tzu Chiu, Ming Shi, *Yangming Wang
PubMed  PDF  doi: 10.1038/s41556-019-0292-7 
Cellular and Molecular Life Sciences | 2019 Jan 29; 76 (9)
Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo
Wen-Ting Guo, *Yangming Wang
PubMed  PDF  doi: 10.1007/s00018-019-03020-9 
Protein & Cell | 2018 Aug 20; 10 (5)
Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program
Xi Chen, Lin Wang, Rujin Huang, Hui Qiu, Peizhe Wang, Da-Ren Wu, Yonglin Zhu, Jia Ming, Yangming Wang, Jianbin Wang, *Jie Na
PubMed  PDF  doi: 10.1007/s13238-018-0572-1 
EMBO reports | 2018 May 07; 19 (6)
Opposing roles of miR-294 and MBNL 1/2 in shaping the gene regulatory network of embryonic stem cells
#Da-Ren Wu, #Kai-Li Gu, Jian-Cheng Yu, Xing Fu, Xi-Wen Wang, Wen-Ting Guo, Le-Qi Liao, Hong Zhu, Xiao-Shan Zhang, *Jingyi Hui, *Yangming Wang
PubMed  PDF  doi: 10.15252/embr.201745657 
Nature Methods | 2018 Feb 12; 15 (3)
Capturing the interactome of newly transcribed RNA
*#Xichen Bao, #Xiangpeng Guo, #Menghui Yin, Muqddas Tariq, Yiwei Lai, Shahzina Kanwal, Jiajian Zhou, Na Li, Yuan Lv, Carlos Pulido-Quetglas, Xiwei Wang, Lu Ji, Muhammad J Khan, Xihua Zhu, Zhiwei Luo, Changwei Shao, Do-Hwan Lim, Xiao Liu, Nan Li, Wei Wang, Minghui He, Yu-Lin Liu, Carl Ward, Tong Wang, Gong Zhang, Dongye Wang, Jianhua Yang, Yiwen Chen, Chaolin Zhang, Ralf Jauch, Yun-Gui Yang, Yangming Wang, Baoming Qin, Minna-Liisa Anko, Andrew P Hutchins, Hao Sun, Huating Wang, Xiang-Dong Fu, *Biliang Zhang, *Miguel A Esteban
PubMed  PDF  doi: 10.1038/nmeth.4595 
Stem Cell Reports | 2017 Nov 01; 9 (5)
A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183–182 Families in Mouse Embryonic Stem Cells
Xi-Wen Wang, Jing Hao, Wen-Ting Guo, Le-Qi Liao, Si-Yue Huang, Xiangpeng Guo, Xichen Bao, Miguel A. Esteban, *Yangming Wang
PubMed  PDF  doi: 10.1016/j.stemcr.2017.08.027 
Nature Structural & Molecular Biology | 2017 Aug 28; 24 (10)
NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing
#Li Jiang, #Changwei Shao, Qi-Jia Wu, Geng Chen, Jie Zhou, Bo Yang, Hairi Li, Lan-Tao Gou, Yi Zhang, Yangming Wang, Gene W Yeo, *Yu Zhou, *Xiang-Dong Fu
PubMed  PDF  doi: 10.1038/nsmb.3455 
Current Opinion in Genetics & Development | 2017 Oct 01; 46
MicroRNAs and RNA binding protein regulators of microRNAs in the control of pluripotency and reprogramming
Jing Hao, Fei-Fei Duan, *Yangming Wang
PubMed  PDF  doi: 10.1016/j.gde.2017.07.001 
Journal of Genetics and Genomics | 2017 Apr 01; 44 (4)
Significant differences of function and expression of microRNAs between ground state and serum-cultured pluripotent stem cells
#Ying Yan, #Xi Yang, Ting-Ting Li, Kai-Li Gu, Jing Hao, Qiang Zhang, *Yangming Wang
PubMed  PDF  doi: 10.1016/j.jgg.2017.01.005 
Artificial Organs | 2016 Dec 07; 41 (5)
Danshen-Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Model
Wei Wei, Yiwei Liu, Qiang Zhang, Yangming Wang, Xiaoling Zhang, *Hao Zhang
PubMed  PDF  doi: 10.1111/aor.12801 
Cell Research | 2016 Jan 08; 26 (3)
Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency
#Kai-Li Gu, #Qiang Zhang, #Ying Yan, #Ting-Ting Li, Fei-Fei Duan, Jing Hao, Xi-Wen Wang, Ming Shi, Da-Ren Wu, Wen-Ting Guo, *Yangming Wang
PubMed  PDF  doi: 10.1038/cr.2016.2 
Journal of Genetics and Genomics | 2015 Mar 01; 42 (3)
Large Noncoding RNAs Are Promising Regulators in Embryonic Stem Cells
Ya-Pu Li, *Yangming Wang
PubMed  PDF  doi: 10.1016/j.jgg.2015.02.002 
The EMBO Journal | 2015 Jan 20; 34 (5)
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency
#Yang Cao, #Wen-Ting Guo, Shengya Tian, Xiaoping He, Xi-Wen Wang, Xiaomeng Liu, Kai-Li Gu, Xiaoyu Ma, De Huang, Lan Hu, Yongping Cai, Huafeng Zhang, *Yangming Wang, *Ping Gao
PubMed  PDF  doi: 10.15252/embj.201490441 
The EMBO Journal | 2014 Dec 17; 34 (3)
Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells
#Yanni Ma, #Nan Yao, #Guang Liu, Lei Dong, Yufang Liu, Meili Zhang, Fang Wang, Bin Wang, Xueju Wei, He Dong, Lanlan Wang, Shaowei Ji, Junwu Zhang, Yangming Wang, *Yue Huang, *Jia Yu
PubMed  PDF  doi: 10.15252/embj.201489957 
Cell Death & Differentiation | 2014 Dec 12; 22 (7)
Suppression of epithelial–mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells
Wen-Ting Guo, Xi-Wen Wang, Yao-Long Yan, Ya-Pu Li, X Yin, Qiang Zhang, Collin Melton, Archana Shenoy, N A Reyes, S A Oakes, *Robert Blelloch, *Yangming Wang
PubMed  PDF  doi: 10.1038/cdd.2014.205 
Protein & Cell | 2014 Jan 01; 5 (1)
Micro-management of pluripotent stem cells
Wen-Ting Guo, Xi-Wen Wang, *Yangming Wang
PubMed  PDF  doi: 10.1007/s13238-013-0014-z 
Cell Reports | 2013 Jul 01; 4 (1)
miR-294/miR-302 Promotes Proliferation, Suppresses G1-S Restriction Point, and Inhibits ESC Differentiation through Separable Mechanisms
*#Yangming Wang, #Collin Melton, Ya-Pu Li, Archana Shenoy, Xin-Xin Zhang, Deepa Subramanyam, *Robert Blelloch
PubMed  PDF  doi: 10.1016/j.celrep.2013.05.027 
Results and Problems in Cell Differentiation | 2011; 53
Cell Cycle Regulation by microRNAs in Stem Cells
Yangming Wang, *Robert Blelloch
PubMed  PDF  doi: 10.1007/978-3-642-19065-0_19 
Cancer Research | 2009 May 12; 69 (10)
Cell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
Yangming Wang, *Robert Blelloch
PubMed  PDF  doi: 10.1158/0008-5472.can-09-0309 
Nature Genetics | 2008 Nov 02; 40 (12)
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation
Yangming Wang, Scott Baskerville, Archana Shenoy, Joshua E Babiarz, Lauren Baehner, *Robert Blelloch
PubMed  PDF  doi: 10.1038/ng.250 
Genes & Development | 2008 Oct 15; 22 (20)
Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs
#Joshua E. Babiarz, #J. Graham Ruby, Yangming Wang, David P. Bartel, *Robert Blelloch
PubMed  PDF  doi: 10.1101/gad.1705308 
Nature Genetics | 2007 Jan 28; 39 (3)
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
Yangming Wang, Rostislav Medvid, Collin Melton, Rudolf Jaenisch, *Robert Blelloch
PubMed  PDF  doi: 10.1038/ng1969 
ACS Chemical Biology | 2006 Jun 20; 1 (5)
Experimental Tests of Two Proofreading Mechanisms for 5′-Splice Site Selection
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/cb6001569 
RNA | 2006 Apr 17; 12 (6)
Efficient RNA 5′-adenylation by T4 DNA ligase to facilitate practical applications
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1261/rna.33106 
Biochemistry | 2006 Mar 7; 45 (9)
Adenosine Is Inherently Favored as the Branch-Site RNA Nucleotide in a Structural Context That Resembles Natural RNA Splicing
Elena Zelin, Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/bi052499l 
RNA | 2005 Dec 22; 12 (2)
A general two-step strategy to synthesize lariat RNAs
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1261/rna.2259406 
Angewandte Chemie International Edition | 2015 Sep 01; 44 (36)
Efficient One-Step Synthesis of Biologically Related Lariat RNAs by a Deoxyribozyme
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1002/anie.200501643 
Nucleic Acids Research | 2005 Jun 20; 33 (11)
A deoxyribozyme that synthesizes 2',5'-branched RNA with any branch-site nucleotide
*E. D. Pratico, Yangming Wang, Scott K. Silverman
PubMed  PDF  doi: 10.1093/nar/gki656 
Biochemistry | 2005 Mar 1; 44 (8)
Directing the Outcome of Deoxyribozyme Selections To Favor Native 3‘−5‘ RNA Ligation
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/bi0478291 
Biochemistry | 2003 Dec 30; 42 (51)
Characterization of Deoxyribozymes That Synthesize Branched RNA
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/bi0355847 
Journal of the American Chemical Society | 2003 Jun 11; 125 (23)
Deoxyribozymes That Synthesize Branched and Lariat RNA
Yangming Wang, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/ja035150z 
Journal of the American Chemical Society | 2003 Mar 5; 125 (9)
Deoxyribozymes with 2‘−5‘ RNA Ligase Activity
Amber Flynn-Charlebois, Yangming Wang, Tracey K. Prior, Imran Rashid, Kelly A. Hoadley, Rebecca L. Coppins, Amanda C. Wolf, *Scott K. Silverman
PubMed  PDF  doi: 10.1021/ja028774y 
Acta Scientiarum Naturalium Universitatis Pekinensis | 2001; 37 (4)
Cre/loxP-mediated Deletion of Transgene in Transgenic Tobacco
Wei Zhen, Yangming Wang, Wei Ding, Xi Chen, Yuanlei Hu, Zhongping Lin
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