实验室文章


同行评审的原始研究论文
总引用5000余次 H指数28

2022年至今

  • 54: Li Z, Li X, Lin J, Wang Y, *Cao H, *Zhou J. Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit. Science China-Life Science 2024 Jul 9. Link. Epub ahead of print. PubMed.

  • 53: #Huang W, #Xiong T, #Zhao YT, Heng J, Han G, Wang P, Zhao Z, Shi M, Li J, Wang JZ, Wu YX, Liu F, *Xi JJ, *Wang Y, *Zhang QC. Computational prediction and experimental validation identify functionally conserved lncRNAs from zebrafish to human. Nature Genetics 2024 Jan; 56(1): 124-135. Link. Epub 2024 Jan 9. PubMed.

  • 52: #Shi F, #Zhang K, Cheng QX, Che S, Zhi S, Yu Z, Liu F, Duan FF, *Wang Y, *Yang N. Molecular mechanism governing RNA-binding property of mammalian TRIM71 protein. Science Bulletin 2024 Jan 15; 69(1): 72-81. Link. Epub 2023 Nov 21. PubMed.

  • 51: Wei X, Yu S, Zhang T, Liu L, Wang X, Wang X, Chan YS, Wang Y, Meng S, *Chen YG. MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice. ACS Nano 2023 Nov 28; 17(22): 22901-22915. Link. Epub 2023 Nov 8. PubMed.

  • 50: Zhang XS, Xie G, Ma H, Ding S, Wu YX, Fei Y, Cheng Q, Huang Y, *Wang Y. Highly reproducible and cost-effective one-pot organoid differentiation using a novel platform based on PF-127 triggered spheroid assembly. Biofabrication 2023 Aug 21; 15(4). Link. PubMed.

  • 49: #Cui Y, #Qi Y, #Ding L, Ding S, Han Z, *Wang Y, #*Du P. miRNA dosage control in development and human disease. Trends in Cell Biology 2024 Jan; 34(1): 31-47. Link. Epub 2023 Jul 5. PubMed.

  • 48: #Mi L, #Shi M, Li YX, Xie G, Rao X, Wu D, Cheng A, Niu M, Xu F, Yu Y, Gao N, Wei W, Wang X, *Wang Y. DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing. Nature Communications 2023 Feb 16; 14(1): 874. Link. PubMed.

  • 47: Huang R, Liu J, Chen X, Zhi Y, Ding S, Ming J, Li Y, Wang Y, *Na J. A long non-coding RNA LncSync regulates mouse cardiomyocyte homeostasis and cardiac hypertrophy through coordination of miRNA actions. Protein & Cell 2023 Mar 16; 14(2): 153-157. Link. Epub 2022 May 28. PubMed.

  • 46: Hu LF, Li YX, Wang JZ, Zhao YT, *Wang Y. Controlling CRISPR-Cas9 by guide RNA engineering. Wiley Interdisciplinary Reviews-RNA 2023 Jan; 14(1): e1731. Link. Epub 2022 Apr 8. PubMed.

  • 45: Wang SH, Hao J, Zhang C, Duan FF, Chiu YT, Shi M, Huang X, Yang J, *Cao H, *Wang Y. KLF17 promotes human naive pluripotency through repressing MAPK3 and ZIC2. Science China-Life Sciences 2022 Oct; 65(10): 1985-1997. Link. Epub 2022 Apr 1. PubMed.

2021年及之前

  • 44: *Guo WT, Wang SH, Zhang XS, Shi M, Duan FF, Hao J, Gu KL, Quan L, Wu YX, Liang Z and *Wang Y. Acidic pH transiently prevents the silencing of self-renewal and dampens microRNA function in embryonic stem cells. Science Bulletin 2021 Jul 15; 66(13): 1319-1329. Link. Epub 2021 Mar 10. PubMed.

  • 43: Zhao YT and *Wang Y. Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron. Cell Discovery 2021 Jun 15; 7(1): 45. Link. PubMed.

  • 42: Wang SH, Zhang C and *Wang Y. microRNA regulation of pluripotent state transition. Essays in Biochemistry 2020 Dec 7; 64(6): 947-954. Link. PubMed.

  • 41: #Hao J, #Yang X, Zhang C, Zhang XT, Shi M, Wang SH, Mi L, Zhao YT, Cao H and *Wang Y. KLF3 promotes the 8-cell-like transcriptional state in pluripotent stem cells. Cell Proliferation 2020 Nov; 53(11): e12914. Link. Epub 2020 Sep 29. PubMed.

  • 40: #Guo CJ, #Ma XK, Xing YH, Zheng CC, Xu YF, Shan L, Zhang J, Wang S, Wang Y, Carmichael GG, Yang L, *Chen LL. Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Cell 2020 Apr 30; 181(3): 621-636.e22. Link. Epub 2020 Apr 6. PubMed.

  • 39: #Wu K, #Liu H, Wang Y, He J, Xu S, Chen Y, Kuang J, Liu J, Guo L, Li D, Shi R, Shen L, Wang Y, Zhang X, Wang J, Pei D, *Chen J. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. Cell Reports 2020 Jan 7; 30(1): 25-36.e6. Link. PubMed.

  • 38: #Zhang C, #Yan YL, #Hao J, *Wang Y. Cellular redox state as a critical factor in initiating early embryonic-like program in embryonic stem cells. Cell Discovery 2019 Dec 10; 5: 59. Link. PubMed.

  • 37: Shi M, Hao J, Wang XW, Liao LQ, *Cao H, *Wang Y. Functional Dissection of pri-miR-290~295 in Dgcr8 Knockout Mouse Embryonic Stem Cells. International Journal of Molecular Sciences 2019 Sep 5; 20(18): 4345. Link. PubMed.

  • 36: Wang Z, Wang L, Liu W, Hu D, Gao Y, Ge Q, Liu X, Li L, *Wang Y, *Wang S, *Li C. Pathogenic mechanism and gene correction for LQTS-causing double mutations in KCNQ1 using a pluripotent stem cell model. Stem Cell Research 2019 Jul; 38: 101483. Link. Epub 2019 Jun 11. PubMed.

  • 35: #Yan YL, #Zhang C, Hao J, Wang XL, Ming J, Mi L, Na J, Hu X, *Wang Y. DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program. PLoS Biology 2019 Jun 21; 17(6): e3000324. Link. PubMed.

  • 34: #Li YP, #Duan FF, Zhao YT, Gu KL, Liao LQ, Su HB, Hao J, Zhang K, Yang N, *Wang Y. A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells. Nature Communications 2019 Mar 25; 10(1): 1368. Link. PubMed.

  • 33: #Wang XW, #Hu LF, Hao J, Liao LQ, Chiu YT, Shi M, *Wang Y. A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool. Nature Cell Biology 2019 Apr; 21(4): 522-530. Link. Epub 2019 Feb 25. PubMed.

  • 32: Guo WT, *Wang Y. Dgcr8 knockout approaches to understand microRNA functions in vitro and in vivo. Cellular and Molecular Life Sciences 2019 May; 76(9): 1697-1711. Link. Epub 2019 Jan 29. PubMed.

  • 31: Chen X, Wang L, Huang R, Qiu H, Wang P, Wu D, Zhu Y, Ming J, Wang Y, Wang J, *Na J. Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene program. Protein & Cell 2019 May; 10(5): 327-346. Link. Epub 2018 Aug 20. PubMed.

  • 30: #Wu DR, #Gu KL, Yu JC, Fu X, Wang XW, Guo WT, Liao LQ, Zhu H, Zhang XS, *Hui J, *Wang Y. Opposing roles of miR-294 and MBNL1/2 in shaping the gene regulatory network of embryonic stem cells. EMBO Reports 2018 Jun; 19(6): e45657. Link. Epub 2018 May 7. PubMed.

  • 29: #Bao X, #Guo X, #Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, *Zhang B, *Esteban MA. Capturing the interactome of newly transcribed RNA. Nature Methods 2018 Mar; 15(3): 213-220. Link. Epub 2018 Feb 12. PubMed.

  • 28: Wang XW, Hao J, Guo WT, Liao LQ, Huang SY, Guo X, Bao X, Esteban MA, *Wang Y. A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183-182 Families in Mouse Embryonic Stem Cells. Stem Cell Reports 2017 Nov 14; 9(5): 1618-1629. Link. Epub 2017 Oct 5. PubMed.

  • 27: #Jiang L, #Shao C, #Wu QJ, Chen G, Zhou J, Yang B, Li H, Gou LT, Zhang Y, Wang Y, Yeo GW, Zhou Y, Fu XD. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nature Structural and Molecular Biology 2017 Oct; 24(10): 816-824. Link. Epub 2017 Aug 28. PubMed.

  • 26: Hao J, Duan FF, *Wang Y. MicroRNAs and RNA binding protein regulators of microRNAs in the control of pluripotency and reprogramming. Current Opinion in Genetics and Development 2017 Oct; 46: 95-103. Link. Epub 2017 Jul 25. PubMed.

  • 25: #Yan Y, #Yang X, Li TT, Gu KL, Hao J, Zhang Q, *Wang Y. Significant differences of function and expression of microRNAs between ground state and serum-cultured pluripotent stem cells. Journal of Genetics and Genomics 2017 Apr 20; 44(4): 179-189. Link. Epub 2017 Feb 22. PubMed.

  • 24: Wei W, Liu Y, Zhang Q, Wang Y, Zhang X, *Zhang H. Danshen-Enhanced Cardioprotective Effect of Cardioplegia on Ischemia Reperfusion Injury in a Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Model. Artificial Organs 2017 May; 41(5): 452-460. Link. Epub 2016 Dec 7. PubMed.

  • 23: #Gu KL, #Zhang Q, #Yan Y, #Li TT, Duan FF, Hao J, Wang XW, Shi M, Wu DR, Guo WT, *Wang Y. Pluripotency-associated miR-290/302 family of microRNAs promote the dismantling of naive pluripotency. Cell Research 2016 Mar; 26(3): 350-66. Link. Epub 2016 Jan 8. PubMed.

  • 22: Li YP, *Wang Y. Large noncoding RNAs are promising regulators in embryonic stem cells. Journal of Genetics and Genomics 2015 Mar 20; 42(3): 99-105. Link. Epub 2015 Feb 12. PubMed.

  • 21: #Cao Y, #Guo WT, Tian S, He X, Wang XW, Liu X, Gu KL, Ma X, Huang D, Hu L, Cai Y, Zhang H, *Wang Y, *Gao P. miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency. EMBO Journal 2015 Mar 4; 34(5): 609-23. Link. Epub 2015 Jan 20. PubMed.

  • 20: #Ma Y, #Yao N, #Liu G, Dong L, Liu Y, Zhang M, Wang F, Wang B, Wei X, Dong H, Wang L, Ji S, Zhang J, Wang Y, *Huang Y, *Yu J. Functional screen reveals essential roles of miR-27a/24 in differentiation of embryonic stem cells. EMBO Journal 2015 Feb 3; 34(3): 361-78. Link. Epub 2014 Dec 17. PubMed.

  • 19: Guo WT, Wang XW, Yan YL, Li YP, Yin X, Zhang Q, Melton C, Shenoy A, Reyes NA, Oakes SA, *Blelloch R, *Wang Y. Suppression of epithelial-mesenchymal transition and apoptotic pathways by miR-294/302 family synergistically blocks let-7-induced silencing of self-renewal in embryonic stem cells. Cell Death & Differentiation. 2015 Jul; 22(7): 1158-69. Link. Epub 2014 Dec 12. PubMed.

  • 18: Guo WT, Wang XW, *Wang Y. Micro-management of pluripotent stem cells. Protein & Cell 2014 Jan; 5(1): 36-47. Link. Epub 2014 Jan 28. PubMed.

  • 17: #Wang Y, #Melton C, Li YP, Shenoy A, Zhang XX, Subramanyam D, Blelloch R. miR-294/miR-302 promotes proliferation, suppresses G1-S restriction point, and inhibits ESC differentiation through separable mechanisms. Cell Reports 2013 Jul 11; 4(1): 99-109. Link. Epub 2013 Jul 3. PubMed.

  • 16: Wang Y, Blelloch R. Cell cycle regulation by microRNAs in stem cells. Results and Problems in Cell Differentiation 2011; 53: 459-72. Link. PubMed.

  • 15: Wang Y, Blelloch R. Cell cycle regulation by MicroRNAs in embryonic stem cells. Cancer Research 2009 May 15; 69(10): 4093-6. Link. Epub 2009 May 12. PubMed.

  • 14: Wang Y, Baskerville S, Shenoy A, Babiarz JE, Baehner L, Blelloch R. Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nature Genetics 2008 Dec; 40(12): 1478-83. Link. Epub 2008 Nov 2. PubMed.

  • 13: Babiarz JE, Ruby JG, Wang Y, Bartel DP, Blelloch R. Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes & Development 2008 Oct 15; 22(20): 2773-85. Link. PubMed.

  • 12: Wang Y, Medvid R, Melton C, Jaenisch R, Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nature Genetics 2007 Mar; 39(3): 380-5. Link. Epub 2007 Jan 28. PubMed.

  • 11: Wang Y, Silverman SK. Experimental tests of two proofreading mechanisms for 5’-splice site selection. ACS Chemical Biology 2006 Jun 20; 1(5): 316-24. Link. PubMed.

  • 10: Wang Y, Silverman SK. Efficient RNA 5’-adenylation by T4 DNA ligase to facilitate practical applications. RNA 2006 Jun; 12(6): 1142-6. Link. Epub 2006 Apr 17. PubMed.

  • 9: Zelin E, Wang Y, Silverman SK. Adenosine is inherently favored as the branch-site RNA nucleotide in a structural context that resembles natural RNA splicing. Biochemistry 2006 Mar 7; 45(9): 2767-71. Link. PubMed.

  • 8: Wang Y, Silverman SK. A general two-step strategy to synthesize lariat RNAs. RNA 2006 Feb; 12(2): 313-21. Link. Epub 2005 Dec 22. PubMed.

  • 7: Wang Y, Silverman SK. Efficient one-step synthesis of biologically related lariat RNAs by a deoxyribozyme. Angewandte Chemie International Edition 2005 Sep 12; 44(36): 5863-6. Link. PubMed.

  • 6: Pratico ED, Wang Y, Silverman SK. A deoxyribozyme that synthesizes 2’,5’-branched RNA with any branch-site nucleotide. Nucleic Acids Research 2005 Jun 20; 33(11): 3503-12. Link. PubMed.

  • 5: Wang Y, Silverman SK. Directing the outcome of deoxyribozyme selections to favor native 3’-5’ RNA ligation. Biochemistry 2005 Mar 1; 44(8): 3017-23. Link. PubMed.

  • 4: Wang Y, Silverman SK. Characterization of deoxyribozymes that synthesize branched RNA. Biochemistry 2003 Dec 30; 42(51): 15252-63. Link. PubMed.

  • 3: Wang Y, Silverman SK. Deoxyribozymes that synthesize branched and lariat RNA. Journal of American Chemical Society 2003 Jun 11; 125(23): 6880-1. Link. PubMed.

  • 2: Flynn-Charlebois A, Wang Y, Prior TK, Rashid I, Hoadley KA, Coppins RL, Wolf AC, Silverman SK. Deoxyribozymes with 2’-5’ RNA ligase activity. Journal of American Chemical Society 2003 Mar 5; 125(9): 2444-54. Link. PubMed.

  • 1: Zhen W, Wang Y, Ding W, Chen X, Hu Y, Lin Z. Cre/loxP-mediated Deletion of Transgene in Transgenic Tobacco. Acta Scientiarum Naturalium Universitatis Pekinensis 2001; 37(4): 477-482. Link